Pneumonia recovery reprograms immune cells of the lung

(Boston)—Researchers have determined that after lungs recover from infection, alveolar macrophages (immune cells that live in the lungs and help protect the lungs against infection) are different in multiple ways and those differences persist indefinitely. How the lungs protect themselves when they are at their healthiest, like in young adult humans, is complex and only…

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PCORI Board approves $12 million to support new research studies

WASHINGTON (January 28, 2020) — The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved $12.2 million to fund four studies comparing the most effective ways to treat a range of health conditions that impose high burdens on patients, their families and the healthcare system. The Board approved $4.2 million in funding for…

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Gene therapy success in chronic septic granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children’s) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic…

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100 years after development, TB vaccines vary in ability to stimulate immune components

Each year, more than 100 million newborns around the world receive vaccinations against Mycobacterium tuberculosis, or TB, which infects about one-quarter of the world’s population. Facilities across the world produce several different formulations of these vaccines, known as Bacille Calmette Guérin (BCG) vaccines. These are given interchangeably, yet new research from the Precision Vaccines Program…

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Ethics and Human Research, January-February 2020

Crowdsourced Research: Vulnerability, Autonomy, and Exploitation Adrian Kwek The use of online crowdsourcing platforms to recruit research participants has become ubiquitous in social, behavioral, and educational research. In what sense are crowd workers vulnerable as research participants, and what should ethics reviewers look out for in evaluating a crowdsourced research protocol? The article examines these…

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Does news coverage of crashes affect perceived blame?

Despite an ever-rising number of pedestrian and bicyclist deaths on U.S. roads each year, there’s no widespread public pressure to improve road safety — a situation influenced by how news articles about auto-pedestrian/bicyclist crashes are written, said Tara Goddard, Texas A&M assistant professor of urban planning. «Adopting simple improvements in crash reporting offers a potentially…

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