A molecular glue to overcome cancer drug resistance?

IMAGE: Structure of the complex containing Rev1 and JH-RE-06. The two copies of the Rev1 protein are shown in dark and light blue, while the small molecule JH-RE-06 wedged in between… view more  Credit: Pei Zhou DURHAM, N.C. — Scientists have discovered a small molecule drug that may stop cancer cells from becoming resistant to chemotherapy.…

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Disturbed sleep linked to mental health problems in natural disaster survivors

SAN ANTONIO — Preliminary results from a new study suggest that sleep disturbances are associated with mental health problems among survivors of a natural disaster even two years after the event. The researchers surveyed survivors two years after the 2010 earthquake in Haiti. Results show that 94% reported experiencing subsequent insomnia symptoms after the disaster.…

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AI tool helps radiologists detect brain aneurysms

IMAGE: HeadXNet team members (from left to right, Andrew Ng, Kristen Yeom, Christopher Chute, Pranav Rajpurkar and Allison Park) looking at a brain scan. Scans like this were used to train… view more  Credit: L.A. Cicero/Stanford News Service Doctors could soon get some help from an artificial intelligence tool when diagnosing brain aneurysms — bulges in…

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Tissue engineering: The big picture on growing small intestines

IMAGE: Fluorescent image of stem cells and progenitor cells. Cells like these can eventually be grown in the laboratory into small intestines to treat babies with severe gastrointestinal challenges. Photo courtesy… view more  Credit: Dr. Grikscheit, Children’s Hospital Los Angeles Babies born prematurely often face intense medical challenges, including intestines that are underdeveloped or diseased. While…

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What to know about rib pain during pregnancy

Women can often experience a wide range of uncomfortable symptoms during pregnancy. One common complaint is rib pain, which has several possible causes that vary by trimester. In most cases, the cause of rib pain is harmless. The growing fetus often causes aches and pains around the ribs due to their position in the womb.…

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Meet the Money Whisperer to the Super-Rich N.B.A. Elite

Every day of Joe McLean’s job, as the premier wealth manager of the N.B.A. elite, requires him to make the kind of purchases that most of us make only once or twice in a lifetime. He bought 25 cars on behalf of his clients last year, and he probably sold nearly as many. He closed…

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Billy Porter Cat-Walks His Way Through Hudson Yards

Billy Porter wanted to go clothes shopping. “I’ll meet you in front of the beehive thing…?” he texted on a bright Friday afternoon when New York had the jaunty air of summer hours. The “beehive thing is” the 15-story structure by Thomas Heatherwick that stands amid the glinting cliffs of Hudson Yards. Mr. Porter had…

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Here’s What Being a Witch Really Means

You could say I was primed to be a witch from an early age. My grandma Trudy used to tell us that she had “healing hands.” According to family lore, she once saved the life of a dying horse that, after she pressed her palms to its flank, stood up and trotted happily away. While…

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Dutch Teenager’s Death Sets Off Debate, and Media Corrections

LONDON — By the time she was 17, the Dutch teenager had written a harrowing memoir recounting repeated sexual assaults and her subsequent experience with post-traumatic stress disorder, depression and anorexia. Last year, when she was 16, she approached an end-of-life clinic in the Netherlands seeking euthanasia or assisted suicide, but was rejected because her…

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Soave Classico Makes a Second Impression

So much of what we think we know about wine is probably wrong. That’s just a fact. And it has a lot to do with how we learn about wine. Much of what we think we know comes from reading something somewhere, or extrapolating generalities from a single bottle, or remembering something somebody said, or…

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