New study provides insight into the mechanisms of blood clots in cancer patients

(Boston)—Researchers have identified a potential new signaling pathway that may help further the understanding of blood clot formation in cancer patients and ultimately help prevent this complication from occurring. A pulmonary embolism generally occurs when a clot from the deep veins of the extremities also known as deep vein thrombosis (DVT) becomes dislodged and travels…

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In a first for cell biology, scientists observe ribosome assembly in real time

LA JOLLA, CA — A team of scientists from Scripps Research and Stanford University has recorded in real time a key step in the assembly of ribosomes—the complex and evolutionarily ancient «molecular machines» that make proteins in cells and are essential for all life forms. The achievement, reported in Cell, reveals in unprecedented detail how…

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Discovery paves the way for blocking malaria transmission in Brazil

The bacteria that form the gut microbiota influence important processes of the human body, such as digestion, nutrient absorption, and defense against pathogens. The same type of relationship is present in most animals, including in the Anhopheles darlingi mosquito, the main vector of malaria in Brazil. In the case of this insect, the composition of…

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Virtual reality would make attending therapy easier for stroke survivors

Researchers have created a virtual reality clinic to make it easier for stroke survivors to attend their physical and occupational therapy sessions. Results from a proof-of-concept study suggest that the technology — and the social connection it facilitates — are effective at encouraging therapy participation. «Physical and occupational therapy are important parts of stroke recovery,…

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Breast cancer recurrence after lumpectomy & RT is treatable with localized RT without mastectomy

Approximately 10% of breast cancer patients treated with lumpectomy (breast-conserving surgery [BCS]) and whole-breast radiation (WBI) will have a subsequent in-breast local recurrence of cancer (IBTR) when followed long term. The surgical standard of care has been to perform mastectomy if breast cancer recurs following such breast-preserving treatment. However, a new multi-center study led by…

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Tiny devices made of DNA detect cancer with fewer false alarms

DURHAM, N.C. — A new cancer-detecting tool uses tiny circuits made of DNA to identify cancer cells by the molecular signatures on their surface. Duke University researchers fashioned the simple circuits from interacting strands of synthetic DNA that are tens of thousands of times finer than a human hair. Unlike the circuits in a computer,…

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Do obesity and smoking impact healing after wrist fracture surgery?

Boston, Mass. — Both obesity and smoking can have negative effects on bone health. A recent study led by a team at Beth Israel Deaconess Medical Center (BIDMC) examined whether they also impact healing in patients who have undergone surgery for fractures of the wrist, or the distal radius, which are among the most common…

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Ohio State-developed drug receives FDA approval for treatment of CLL and SML

COLUMBUS, Ohio — On Nov. 21, 2019, the U.S. Food and Drug Administration (FDA) approved the use of the drug acalabrutinib for first-line therapy in chronic lymphocytic leukemia (CLL) and small cell lymphoma (SCL). This is the first full approval of the targeted drug therapy, which was developed and tested at The Ohio State University…

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Predicting vulnerability to Alzheimer’s disease and delirium

Boston, Mass. — Marked by acute temporary confusion, disorientation and/or agitation, postoperative delirium is the most common post-surgical complication in older adults, striking as many as half of adults older than 65 who undergo high-risk procedures such as cardiac surgery or hip replacements. Postoperative delirium is also tightly linked to Alzheimer’s disease (AD). Although each…

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