Early trauma influences metabolism across generations

People who live through traumatic experiences in childhood often suffer long-lasting consequences that affect their mental and physical health. But moreover, their children and grand-children can also be impacted as well. In this particular form of inheritance, sperm and egg cells pass on information to offspring not through their DNA sequence like classical genetic heredity,…

Details

Research could change how blood pressure is managed in spinal cord injury patients

New research from the International Collaboration on Repair Discoveries (ICORD) challenges the current standard for managing blood pressure in people with spinal cord injury (SCI). The findings, published today in Nature Communications, could lead to a change in the way newly injured patients have their blood pressure managed, potentially improving their chances of retaining more…

Details

Start-up awarded grant to develop contrast agent for early detection of liver disease

ATLANTA—Inlighta Biosciences, LLC, a start-up company led by Jenny Yang, Regents’ Professor of Chemistry at Georgia State University, has been awarded a National Institute of Health grant to accelerate development of a magnetic resonance imaging contrast agent to detect liver fibrosis, formation of scar tissue in the liver caused by alcoholic and non-alcoholic fatty liver…

Details

New bioprosthetic valve for TAVR fails to demonstrate non-inferiority

NEW YORK — October 15, 2020 — In a randomized clinical trial, SCOPE II, a new self-expanding bioprosthetic valve used in transcatheter aortic valve replacement (TAVR) failed to demonstrate non-inferiority compared to an existing self-expanding valve. Findings were reported today at TCT Connect, the 32nd annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT…

Details

Results from the REFLECT II Trial reported at TCT Connect

NEW YORK — October 15, 2020 — The REFLECT II randomized clinical trial evaluating the safety and efficacy of a device designed to reduce cerebral embolization and ischemic stroke, complications of transcatheter aortic valve replacement (TAVR), found that the device met the primary safety endpoint compared to historical controls but did not demonstrate superiority of…

Details

Results from the MITHRAS trial reported at TCT Connect and published in Circulation

NEW YORK — October 15, 2020 — The MITHRAS randomized clinical trial found that interventional closure of an iatrogenic atrial septal defect (iASD) driven by transcatheter mitral valve repair (TMVR) was not superior to conservative medical treatment with regard to the primary endpoint of change in six-minute walking distance. Findings were reported today at TCT…

Details

ISSCR’s stem cell based clinical trials guide recognized by Tech Spotlight

Skokie, IL—The ISSCR’s Stem Cell-Based Clinical Trials: Practical Advice for Physicians and Ethics/Institutional Review Committees was honored today by Tech Spotlight at Harvard Kennedy School’s Belfer Center. Tech Spotlight recognizes the technologists, activists, and policymakers who are thoughtfully creating and using technology in ways to protect the public good and help shape a better future.…

Details

Scientists Synthesize Jawbones From Pig Fat

In patients with congenital defects or who have suffered accidental injuries, the jawbone is nearly impossible to replace. Curved and complex, the bone ends with a joint covered with a layer of cartilage. Both parts must withstand enormous pressures as people chew. “It is one of the most loaded bones in the human body,” said…

Details

Biden’s Covid Response Plan Draws From F.D.R.’s New Deal

WASHINGTON — Joseph R. Biden Jr. is preparing for the biggest challenge he would face if elected president — ending the coronavirus pandemic — by reaching back nearly a century to draw on the ideas of President Franklin D. Roosevelt, whose big-government policies lifted the country out of the Great Depression and changed the shape…

Details