The COVID-19 pandemic is undoubtedly the most challenging global health burden since the 2nd World War. The pandemic has raised social awareness on the importance of effective and timely diagnosis that may help minimize the risk of contracting and spreading COVID-19. Thanks to the advancement of micro- and nano-technology, biosensing has become a booming research field in recent years. However, barriers to the adoption are preventing the clinical communities to employ new biosensing techniques for the medical diagnosis or decision-making.

Advances in Biosensing Technology for Medical Diagnosis is therefore edited to summarize the state-of-art and to shed light on the working principles of various kinds of advanced biosensing technologies. More importantly, this book also documents the clinical validations on how the up-to-date biosensing technologies may be applied to for instance diagnosing infectious diseases and neurodegenerative diseases.

The contents of this book are expected to benefit not only students, researchers and clinicians in specialized fields but also policy makers and regulatory authorities in charge of diagnostic medical devices. While the majority of global effort is centered on developing solutions against the coronavirus at this point, this book is published with the hope to contribute advice in the biosensing aspect as well as bringing clues to the world in response to next disastrous pandemic.

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About the Editors:

Dr. Han-Sheng Chuang is currently a full professor in the Department of Biomedical Engineering at National Cheng Kung University in Taiwan. Dr. Chuang received his bachelor and master degrees from the Department of Mechanical Engineering at National Cheng Kung University in 1998 and 2000, respectively. He joined Industrial Technology Research Institute (ITRI) as a R&D engineer in 2001. In 2005, he was awarded a competitive fellowship from Ministry of Education, Taiwan. After then, he worked with Professor Steve T. Wereley for advanced microfluidics and received his Ph.D. from the School of Mechanical Engineering at Purdue University in 2010. He and his research colleagues entered the finalists of the prestigious Burton D. Morgan Business Competition in 2008 and 2009, respectively. After graduation, he received an appointment as a postdoctoral researcher at University of Pennsylvania and worked with Professor Haim H. Bau on cell sorting and Caenorhabditis elegan. Since starting the current position, he has received the 2014 & 2019 Young Scholar Career Grants from the Ministry of Science and Technology, the 2015 Young Scholar Award from the Taiwan Comprehensive University System, the 2016 Teaching Excellence Award and the 2020 Research Excellence Award from NCKU. In addition, he was also a cofounder of a US-based start-up, Microfluidic Innovations, since 2009 and a board member of the Association for Chemical Sensors in Taiwan. Dr. Chuang has dedicated to microfluidics more than a decade. His research interests are mainly focused on biomicrofluidics, Bio-MEMS/NEMS, optical diagnostics, and C. elegans.

Dr. Megan Yi-Ping Ho is currently an Assistant Professor in the Department of Biomedical Engineering at The Chinese University of Hong Kong. She received her bachelor and master degrees in Power Mechanical Engineering from National Tsing-Hua University, Taiwan. She received her Ph.D. in Mechanical Engineering from the Johns Hopkins University in USA. After her postdoctoral training with Duke University in USA, she received the Young Elite Researcher Award from the Danish Research Council for Independent Research and started her independent career in the Interdisciplinary Nanoscience Centre and the Department of Molecular Biology and Genetics at Aarhus University in Denmark. She is also a co-founder of two start-up companies situated in Demark, Zymonostics and vPCiR, focusing on enzyme-based diagnostics. Her research team is focused on developing nanosensors and microfluidics as diagnostic tools to expand the capacity of disease detection and treatment evaluation.

Keywords:

Biosensor, Microfabrication, Nanotechnology, Micro/nano-fluidics, Infectious Diseases, Neurodegenerative Diseases, Medical diagnosis, IVD, POCT, Medical devices

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