Creating a safe CAR T-Cell therapy to fight solid tumors in children

Chimeric Antigen Receptor T-cell therapy–CAR T–has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain CAR T against neuroblastoma revealed toxic effects. Now, a group of scientists at Children’s Hospital Los Angeles have developed a modified version of CAR T…