How Barely-There Botox Became the Norm

Kathryn Gongaware, a 32-year-old yoga teacher and comedian in Chicago, was always curious about Botox, but it wasn’t until she started mentioning it to friends and realized that people she wouldn’t have expected (including her au-natural-everything acupuncturist) were getting it that she felt comfortable making the jump at age 30. “The more people were open…

Emergent BioSolutions: Top Official Warned That Vaccine Plant Had to Be ‘Monitored Closely`

Mr. de Notaristefani, a former top executive at two major pharmaceutical companies, cited “significant” personnel problems, writing that plans to increase staffing seemed “inadequate to enable the company to manufacture at the required rate.” He also noted that audits by the F.D.A. and individual companies that had hired Emergent “highlighted the need for extensive training…

Research shows cytonemes distribute Wnt proteins in vertebrate tissue

Scientists have made a pivotal breakthrough in understanding the way in which cells communicate with each other. A team of international researchers, including experts from the University of Exeter’s Living Systems Institute, has identified how signalling pathways of Wnt proteins – which orchestrate and control many cell developmental processes – operate on both molecular and…

A new treatment for metastatic lung cancer

A new phase 3 randomized clinical trial overseen by CU Cancer Center member Chad Rusthoven, MD, and Vinai Gondi, MD, from Northwestern University, is testing whether a new treatment approach could result in improved outcomes for patients with small cell lung cancer (SCLC) that has spread to the brain. Funded by the National Cancer Institute…

Autism gene study finds widespread impact to brain’s growth signaling network

JUPITER, FL — Damage to the autism-associated gene Dyrk1a, sets off a cascade of problems in developing mouse brains, resulting in abnormal growth-factor signaling, undergrowth of neurons, smaller-than-average brain size, and, eventually, autism-like behaviors, a new study from Scripps Research, Florida, finds. The study from neuroscientist Damon Page, PhD, describes a new mechanism underlying…