The true spread of SARS-CoV-2 infection is much greater than that observed by capturing only swab-diagnosed COVID-19 cases

As part of the MAINSTREAM project, Favalli and colleagues conducted a seroprevalence cross-sectional study between 4th May and 16th June 2020toestimate the prevalence of anti-SARS-CoV-2 antibodies in a large cohort of people with rheumatoid arthritis (RA) or spondyloarthritis (SpA) treated with biologic or targeted synthetic disease modifying anti rheumatic drugs (b/tsDMARDs) in a COVID-19 high-endemic…

Researchers find losartan is not effective in reducing hospitalization from mild COVID-19

MINNEAPOLIS/ST. PAUL (06/18/2021) — University of Minnesota Medical School researchers determined that the common blood pressure medication, losartan, is not effective in reducing hospitalization for mildly-ill COVID-19 outpatients. In the multicenter, randomized, double-blinded clinical trial, non-hospitalized patients recently diagnosed with COVID-19 were given either losartan or a placebo and monitored for 15 days. The study’s…

Overcoming a newly recognized form of resistance to modern prostate cancer drugs

IMAGE: Neuroendocrine prostate cancer cells. view more  Credit: Dr. Aaron Udager, Michigan Medicine Cancer cells have an uncanny ability to evolve and adapt to overcome the treatments used against them. While patient survival has been extended by modern drugs that block the production or action of male hormones that fuel prostate cancer — androgen receptor inhibitors…

Will reduction in tau protein protect against Parkinson’s and Lewy body dementias?

IMAGE: Laura Volpicelli-Daley view more  Credit: UAB BIRMINGHAM, Ala. – Will a reduction in tau protein in brain neurons protect against Parkinson’s disease and Lewy body dementias? A new study, published in the journal eNeuro, suggests the answer is no. If this is borne out, that result differs from Alzheimer’s disease, where reducing endogenous tau levels…

The end of Darwin’s nightmare at Lake Victoria?

Lake Victoria, which came under the spotlight in 2004 by the documentary “Darwin’s nightmare”, is not only suffering from the introduction and commercialisation of the Nile perch. A study lead researchers from the University of Liège (Belgium) has highlighted other worrying phenomena, particularly climatic ones, which have an equally important impact on the quality of…

New artificial heart shows promising results in ‘auto-mode’ — initial clinical experience reported in ASAIO Journal

June 18, 2021 – An experimental artificial heart includes an autoregulation control mechanism, or Auto-Mode, that can adjust to the changing needs of patients treated for end-stage heart failure. Outcomes in the first series of patients managed with the new heart replacement pump in Auto-Mode are presented in the ASAIO Journal, official journal of the…